مسار بولونيا

حسام عبد العباس مطشر محمد

السنة عنوان البحث نشر البحث
2024 Estimation of Serum Level of Neurokinin Ain Patients with Per-iodontitis in Association with Chronic Migraine Disease (Obser-vational Case Control Study) CENTRAL ASIAN JOURNAL OF MEDICALANDNATURALSCIENCES
Recently, a relationship was found between periodontitis and chronic migraine. However, there is no evidence of the association between periodontitis and Neurokinin A (NKA) level in chronic migraine patients. As a result, we aimed to measure and compare serum levels of NKA in study and control groups in order to determine whether periodontitis is associated with chronic mi-graine disease activation. Eightytwo (82) males and females above the age of 18 were recruited. Subjects were divided into four groups: 27 patients with chronic migraine and periodontitis, 27 patients with chronic migraine and clinically healthy periodontium, 20 patients systemically healthy with periodontitis and eight subjects with clinically healthy periodontium and without any systemic disease. Assessment of periodontal status was carried out for all participants. Socio demographic data and comorbidities were assessed by means of a standard questionnaire then blood samples were collected and serum concentrations were separated for NKA. The serum level of NKA were higher in the control group (38±40) and there was a significant difference between the other groups when compared to the control group (P=0.003) and there was a weak negative significant correlation between neurokinin A and clinical periodontal parameters (BOP, Cal, and PPD) between all study groups. According to the findings of this study, the control group had a higher level of serum NKA. As a result, this peptide could be considered an indicator of disease severity and activity for both periodontitis and chronic migraine diseases. So far, no research has backed up our findings. Longitudinal studies are required to validate our findings.