مسار بولونيا
EN

اسامة عزيز حسين مجلي الحميدي

السنة عنوان البحث نشر البحث
2023 Antioxidant Activity and Heart Diseases International Journal of Medical Science and Clinical Research Studies
Cardiovascular disease (CVD), which are complex conditions with many pathophysiologic pathways, has increased oxidative stress as a possible common cause. For a cell to function normally, reactive oxygen species (ROS) and antioxidants must coexist in a delicate balance. High levels of ROS damage large cellular molecules including DNA, lipids and proteins, ultimately leading to necrosis and death, although their primary function is essential to shed light on biological processes. Oxidative stress, the leading cause of death globally in people with cardiovascular disease, has an impact on a variety of disorders. An increase in reactive oxygen species leads to a decrease in the availability of nitric oxide, which in turn leads to vasoconstriction and arterial hypertension. Reactive oxygen species also impair myocardial calcium processing by inducing apoptotic and hypertrophic signaling, which promote cardiac remodeling and arrhythmias. Last but not least, ROS has been shown to promote the growth of atherosclerotic plaques. This paper seeks to give an overview of oxidative stress in CVD with a focus on endothelial dysfunction before looking more closely at how it affects the most prevalent of these diseases. In order to reduce the impact of oxidative stress on CVD, appropriate nutrition and diets are reviewed afterwards.