مسار بولونيا
AR
Research Hossam Samir El-Sawy Seleman
Polymeric nanoparticles: Promising platform for drug delivery
2017 International Journal of Pharmaceutics
Nano medicine had viewed countless breakthroughs in drug delivery implementations. The main objective of nanotechnology application in delivering and carrying many promising therapeutics is to assure drugs carriage to their action sites, to maximize the pharmacological desired influence of remedies and to overcome their limitations and drawbacks that would hinder the required effectiveness. One of these applications was the particulates type of nano-range in size and tremendous impact in achievement. About this specific diversity of particulates, the different elaboration methodologies, mandatory and elementary components for design, and examples of splendid success stories for these particulates were emphasized in this humble review. Challenges such as oral delivery probability for peptide moieties and enhancement the harshly passage process of drugs across the blood brain barriers were accepted and defeated by the almost insurmountable latterly mentioned particulates. Behold, the polymeric nanoparticles.
Stimuliresponsive nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives
2018 ACS Nano
The microenvironment characteristics of solid tumors, renowned as barriers that harshly impeded many drug-delivery approaches, were precisely studied, investigated, categorized, divided, and subdivided into a complex diverse of barriers. These categories were further studied with a particular perspective, which makes all barriers found in solid-tumor micromilieu turn into different types of stimuli, and were considered triggers that can increase and hasten drug-release targeting efficacy. This review gathers data concerning the nature of solid-tumor micromilieu. Past research focused on the treatment of such tumors, the recent efforts employed for engineering smart nanoarchitectures with the utilization of the specified stimuli categories, the possibility of combining more than one stimuli for much-greater targeting enhancement, examples of the approved nanoarchitectures that already translated clinically as well as the obstacles faced by the use of these nanostructures, and, finally, an overview of the possible future implementations of smart-chemical engineering for the design of more-efficient drug delivery and theranostic systems and for making nanosystems with a much-higher level of specificity and penetrability features.
Maximizing the therapeutic efficacy of imatinib mesylate–loaded niosomes on human colon adenocarcinoma using Box-Behnken design
2017 Journal of pharmaceutical sciences
Date seed oil loaded niosomes: development, optimization and anti-inflammatory effect evaluation on rats
2018 Drug development and industrial pharmacy
Effect of nanovesicular surface-functionalization via chitosan and/or PEGylation on cytotoxicity of tamoxifen in induced-breast cancer model
2022 Life Sciences
Oleic acid–reinforced PEGylated polymethacrylate transdermal film with enhanced antidyslipidemic activity and bioavailability of atorvastatin: A mechanistic ex-vivo/in-vivo analysis
2021 International Journal of Pharmaceutics
Fluticasone propionate–loaded solid lipid nanoparticles with augmented anti-inflammatory activity: Optimization, characterization and pharmacodynamic evaluation on rats
2021 Journal of Microencapsulation
PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide
2023 Drug Delivery
Enhanced efficacy, cellular uptake, and antiangiogenic activity of the optimized imatinib mesylate-loaded proniosomal-derived nanovesicles
2021 Journal of Drug Delivery Science and Technology
Can Essential Oils/Botanical Agents Smart-Nanoformulations Be the Winning Cards against Psoriasis?
2023 pharmaceutics
Nanosponge for Enhancing Solubility and Bioavailability of Oral Drugs: Review
2023 International Journal of Applied Pharmaceutics