مسار بولونيا
EN

وسام باسم محمد التميمي

السنة عنوان البحث نشر البحث
2021 HISTOPATHOLOGICAL CHANGES DUE TO TOXIC EFFECT OF AFLATOXIN B1 ON LIVER, KIDNEY AND THERAPEUTIC / PREVENTIVE ROLE OF CAMEL MILK Biochem. Cell. Arch. Vol. 21, No. 1, pp. 741-749, 2021
ABSTRACT : This study performed to investigate toxic effects of aflatoxin B1 (AFB1) through measurement of body weights, and histopathological examination of hepatic and renal tissues; with targeting thereutic role of camel milk in improving of health status. Totally, 32 male rabbits were prepared initially, divided equally to GC, GE1, GE2 and GE3 groups that received respectively water during the 1st (first 38 days) and 2nd (second 38 days) experiments, AFB1 in 1st and camel milk in 2nd, 130µg/ Kg AFB1 in 1st and water in 2nd and camel milk in 1st and AFB1 in 2nd experiment. In comparison to values of zero-time, there significant decrease in values of GE1 and GE2 in 1st experiment; but not in 2nd experiment that showed a significant improvement in values of GE1, and no significant changes in values GE2. For GE3, insignificant differences were showed in study experiments. Histopathologically, hepatic tissues for rabbits received AFB1 were showed severe fatty changes, apoptosis, MNCs infiltration, congestion and dilation of sinusoids, hepatic vein thrombosis, severe degenerative hydropic degeneration, dilation in bile duct, hyperplasia of lining epithelium, necrosis in some lining epithelium, and cellular debris with fibrosis; whereas, there vascular degeneration in epithelial cells, congestion of glomerular capillaries, and dilation with extensive necrosis in tubules of renal tissues. In animals treated by camel milk, hepatic tissues showed significant accumulation of macrophages and lymphocytes in parenchyma, granulomatous lesion and fibrosis; whereas, significant MNCs infiltration in cortex, moderate fibrinous exudates in vascular wall, and swelling of tubules were seen in renal tissues.